Postdoc in the Toxicology and Drug Metabolism Group at the Department of Pharmacy

Københavns Universitet (KU)

Ph.d. & forskning
Storkøbenhavn
Øresundsregionen

Faculty of Health and Medical Sciences
University of Copenhagen

The Department of Pharmacy at the Faculty of Health and Medical Sciences, University of Copenhagen, is looking for a highly motivated and dynamic researcher for a 15 month Postdoc position in the Toxicology and Drug Metabolism Group.

Our research
The Toxicology and Drug Metabolism Group has great expertise in in vitro and in vivo research on the endocrine disrupting potential of pharmaceuticals and applies enzyme and cell based in vitro assays as well as in vivo assays and analytical tools such as HPLC-MSMS. Research related to this position will be performed in the Toxicology and Drug Metabolism Group under supervision of Assoc. Prof. Andreas Kretschmann in collaboration with the Microscale Analytical Systems Group (Prof. Jörg P. Kutter). Information about the two research groups as well as the Department of Pharmacy can be found under http://pharmacy.ku.dk/research/ .

Your job
Research related to this position is highly interdisciplinary and is based at the intersection of in vitro endocrine toxicology, microfluidic technology, and (bio)analytical chemistry. It aims at the development of novel in vitro assays for toxicity screening of drug enantiomers. More specific, we want to develop a microfluidic live-cell array, which can screen for the disrupting potency of drug enantiomers towards human steroidogenesis within very short time-frames and with low costs. Furthermore, this assay shall allow for a mechanistic evaluation of the endocrine toxicity of drugs. The work includes culturing of endocrine cells, design and fabrication of microfluidic lab-on-a-chip systems, miniaturization of the traditional H295R steroidogenesis assay, i.e., adaption and characterization of endocrine cells to and under microfluidic conditions, and application of the developed microfluidic assay to toxicity studies. Furthermore, quantification of drug compounds and steroid hormones with (chiral) HPLC-MSMS. This position includes (to a minor extent) teaching duties such as supervision of students and teaching in courses related to pharmaceutical sciences at bachelor and master levels.

The main responsibilities of the Postdoc are research, including publication/scientific communication of research results, as well as research-based teaching.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Required qualifications:

  • Candidates should hold a PhD degree in an area related to the above mentioned research (e.g., in pharmaceutical sciences, biochemistry, bioengineering, mechanistic/ endocrine toxicology, (bio)analytical chemistry, or similar).
  • Calculated from the application deadline, no more than 4 years must have elapsed since you obtained your PhD. Leaves of absence such as maternity/paternity leave, illness or family care leave, leave for military service, humanitarian aid work, etc. will be taken into account.
  • Candidates who can document expertise and original scientific production in in vitro toxicology using cell based assays, microfluidic live-cell assays (e.g., organ on-a-chip devices) and/ or lab-on-a-chip technology are preferred. Furthermore, experience with analytical tools like (chiral) HPLC-MSMS is considered an advantage.
  • An excellent publication record is required.
  • Teaching qualifications are considered an advantage.

Place of employment
The place of employment is at the Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and state of the art instrumentation.

Terms of employment
The employment as postdoc is a full time and fixed-term position for 15 months. Starting date is the 4th of May 2020.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 33,600 DKK/ approx. 4,480 Euro (April 2018-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions
For further information, please contact Assoc. Prof. Andreas Kretschmann (andreas.kretschmann@sund.ku.dk) or the Head of Department Flemming Madsen, (flemming.madsen@sund.ku.dk );www.sund.ku.dk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. Curriculum vitae incl. education, research experience and research interest, teaching experience, previous employments, language skills and other relevant skills.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

5. Teaching portfolio. Please find a guide to your portfolio here: https://employment.ku.dk/faculty/recruitment-process/job-application-portfolio/

Application deadline: 5 January 2020
We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 10

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Info
Ansøgningsfrist: 05-01-2020

Ansættelsesdato: 04-05-2020

Arbejdstid: Fuldtid

Afdeling/Sted: Instititut for Farmaci


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