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PhD fellow in Clinical Immunology

Region Nordjylland



The Department of Clinical Immunology, Aalborg University Hospital and the Faculty of Health Science at Aalborg University is offering a PhD scholarship in Autoimmune Neutropenia commencing 01.11. 2020 or by individual agreement.

Description of the department and the scientific environment
Department of Clinical Immunology is the regional department for Clinical Immunology and Transfusion Medicine. The department carries out immunological diagnostics, including inborn immunodeficiencies and autoimmune diseases as well as blood bank management and production of blood products. Research is an integrated part of the department and we have a dedicated group of MSc’s, medical doctors and bioengineers involved in our research group. The research area covers autoimmune diseases, immunodeficiencies, genetic association studies, extracellular vesicles and cancer immunotherapy. The department has national reference laboratory status for investigation of immune neutropenia’s.
The department has about 105 employees, including two associate professors, eight medical doctors and six researchers. The department is equipped with modern instruments for molecular and cellular analysis. The department will be located in the New Aalborg University Hospital from 2022.

The positions and project descriptions
The research is founded in our existing research in primary immune neutropenia in children. The PhD. fellow will be in close collaboration with paediatric departments. On daily basis, the student will be associated to our molecular biology laboratory. For the right person, there will be possibilities for a post doc position following the PhD project.

The PhD. project
A study of immune regulatory gene polymorphisms and FCGR3B copy number variation in relation to pathognomonic autoantibodies in primary autoimmune neutropenia of infancy.

Background
Primary autoimmune neutropenia of infancy and childhood (AIN) is the most frequent cause of severe neutropenia in children and can lead to severe bacterial infections. The disease is caused by autoantibodies directed against membrane proteins on neutrophil granulocytes. The antibodies can be directed against HNA (Human Neutrophil Antigen) antigens, most frequently epitopes on the fc gamma receptor 3 (bFcγR3b), a receptor involved in immunoregulation, and encoded by the FCGR3B gene. The etiology of AIN has yet to be elucidated and the genetic background for the disease remains unknown. The goal of this study is to investigate inborn genetic variation in children with AIN.

Main objectives of the study

    • Establish an assay and determine association between FCGR3B copy number variation and AIN
    • Investigate the association between 50 single nucleotide polymorphism ( SNPs) in immune regulatory genes and AIN
    • To compare a novel and rapid method for detection of antineutrophil antibodies: LabScreen MULTI (One Lambda Inc.) with a standard flow cytometric method and investigate the asociation to genetic risk factors.Research partners
      Kaspar René Nielsen, associate professor, MD. PhD. Department of Clinical Immunology, Aalborg University
    • Hospital. Rudi Steffensen, Ph.D. Department of Clinical Immunology, Aalborg University
      Hospital. Tanja Masmas, Chief Physician, Department of Paediatrics, Rigshospitalet. Petter Höglund.
      Professor in Immunology, Karolinska Institutet, Stockholm, Sweden
    Job description
    The position is available for a 3-year period and your key tasks as a PhD student are:
    To manage and carry through your research project
    • Attend PhD courses
    • Write scientific articles and your PhD thesis
    • Teach and disseminate your research
    • Abroad stay at an external research institution for a few months

    Formal requirements
    We are seeking highly motivated applicants with an MSc degree in molecular biology, medical science, medicine with industrial specialisation or similar related fields with the following competences:

    • Theoretical and practical experience with molecular biology and Polymerase chain reaction (PCR) analysis
    • Oral examinations and interpretation
    • Epidemiology and statistics on advanced level
    • Hands-on experience with molecular biology analysis and laboratory cell work

    Good oral and written English competences
    It will be highly advantageous to have one or more of the following qualifications:

    • Publications in peer-reviewed scientific journals or knowledge to scientific journal writing
    • Experience with scientific work

    Salary and terms of employment
    The salary and terms of employment follow the current agreement between the Ministry of Finance and the union of academics (AC). The average working hours per week is 37 hours.

    Contact:
    Further information can be obtained by associate professor, MD, Ph.D. Kaspar René Nielsen, k.nielsen@rn.dk

    Om Region Nordjylland
    Region Nordjylland leverer velfærd til 580.000 nordjyder inden for sundhed, regional udvikling og det specialiserede socialområde. Vi er 15.000 medarbejdere om opgaven, heraf 90 % inden for sundhed. Vi vil skabe et godt liv for alle nordjyske borgere og et sammenhængende Nordjylland. Vi gør digital kontakt med sundhedsvæsnet til et nemt og naturligt valg for nordjyderne. Læs mere om regionen på www.rn.dk.

    Fakta Arbejdssted Aalborg Universitetshospital

    Adresse Urbansgade 36
    9000 Aalborg

    Arbejdstid Fuldtid

    Varighed Tidsbegrænset ansættelse

    Ansøgningsfrist 12. oktober 2020

    Tiltrædelse 01. november 2020

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