Postdoc in GPCR mechanosensing

We are looking for a highly motivated postdoc for a 2 year position to commence 1 November 2024 or as soon as possible thereafter.

The project is part of a larger cross institutional synergy project called ‘GPCRmec: Quantitative investigation of GPCR mechanosensation’ financed by the Novo Nordisk Foundation.

Our research
You will join the Mathiasen Group in the Department of Biomedical Sciences, in the theme of Molecular and Translational Pharmacology.

The Mathiasen group is one of multiple groups in the theme studying G protein-coupled receptors (GPCRs). We offer a dynamic and social work environment, where students at all levels (BSc, MSc, and PhD), postdocs, technicians and scientists from various cultures work together on a variety of interdisciplinary projects, and you will engage and collaborate with several colleagues in the group and theme.

Information on the Mathiasen group

The Department of Biomedical Sciences (BMI) is an interdisciplinary department with research groups focused on topics spanning from basic to translational science. Information on the department can be found at BMI

The Project
The transmembrane G protein-coupled receptors (GPCRs) take part in a myriad of physiological processes and are involved in numerous pathologies. The project aims to investigate the role of GPCR mechanosensation in tissue-specific GPCR pharmacology.

In the project will include the establishment of novel assays for the detection of mechanosensation at the subcellular level, using a combination of fluorescence microscopy and live cell GPCR signalling assays.

The project will go deep to understand which mechanisms are at play when GPCR receptors respond to mechanical stress of various kind.

A close collaboration with researchers from the Neils Bohr Institute and the Department of Chemistry will ensure access to the needed crossdisciplinarity expertise and equipment (e.g. the C-trap LUMICKS system used for optical trapping).

Profile
We are looking for a highly motivated and enthusiastic scientist, within the field(s) of Biophysics, Nanoscience, Molecular or Cell Biology, Biochemistry or alike, with the following competencies and experience:

Essential experience and skills:

• You have obtained PhD degree or equivalent
• You are experienced in confocal imaging or other types of fluorescence imaging
• You are experienced in investigating GPCR receptor function
• You are experienced in working with mammalian cell culture
• You are experienced in working with standard molecular biology techniques (e.g. used for cloning)
• You have good communication skills and ability to work in teams with e.g. MSc and PhD students
• You have excellent English skills both written and spoken

Desirable experience and skills:

• Experience with optical trapping
• Experience with image analysis procedures for quantitative microscopy
• Experience with other cell membrane manipulation techniques e.g. cell-stretcher or micropipettes
• Experience with programming (MATLAB/Phyton)
• Experience using bioinformatics software e.g SnapGene or Geneious Prime

Place of employment
The place of employment is at the Department of Biomedical Sciences, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories and access to state-of-the-art equipment.

Terms of employment
The average weekly working hours are 37 hours per week.

The position is a fixed-term position limited to a period of 2 years. The starting date is November 1st 2024 or after agreement.

Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 38,500 DKK/approx. 5,100 EUR (April 2024 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Questions
For further information please contact Signe Mathiasen; Signe.Mathiasen@sund.ku.dk;
www.sund.ku.dk
Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure
Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

• Motivated letter of application (max. one page).
• CV incl. education, work/research experience, language skills and other skills relevant for the position.
• A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
• List of publications.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held by the end of September 2024.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background

Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Kontakt
Signe Juul Mathiasen
E-mail: [email protected]

Info
Ansøgningsfrist: 01-09-2024

Ansættelsesdato: 01-11-2024

Arbejdstid: Fuldtid

Afdeling/Sted: Department of Biomedical Sciences