Postdoc in Real Time Detection of Mass Transport in Engineered Tissue – DTU Health Tech

Join the 4DMAPPER project to develop a label-free molecular profiler for 4D mapping in ex-vivo tissue. Create novel cell culture ware for a custom Raman microscope to detect unlabelled drug molecules. Experience in biomaterials, organ-on-chips, polymeric microfabrication, hydrogels, and cell culture required.
Are you passionate about guiding tissue formation using custom designed cell culture ware, and use these tissue models to study drug mass transport in time and space, you may be our new post-doc.

With the project 4DMAPPER - 4D mapping of transport and metabolism in organ on a chip, we develop a novel, label-free dynamic molecular profiler with high resolution in space and time (4D). 4DMAPPER will enable localized measurements of unlabeled molecules in 3D, and real-time visualization of mass transport in ex-vivo tissue and other 3D materials.

Responsibilities and qualifications
We are seeking a highly motivated Postdoctoral Researcher to join our dynamic team. You will be responsible for designing, fabricating, and validating novel cell culture ware to be used in a custom-built Raman microscope for the detection of unlabelled drug molecules. Additionally, you will utilize the Raman microscope to measure transport in hydrogels and tissue models. This role involves close collaboration with a fellow post-doc who is developing the Raman microscope.

Your primary tasks will be:

• Design and fabricate polystyrene cell culture ware using 3D printing, vacuum forming, and laser micromachining.
• Validate the usability of the devices for mass transport studies by comparing fluorescent markers with corresponding unlabelled markers and drugs detected using Raman microscopy.
• Employ 3D models to study mass transport using simpler 3D cancer models and intestine barrier models
• Measure and model mass transport of drugs and molecules in time and space (in collaboration with a fellow post-doc) across various gels and artificial tissues.

We expect that you have documented experience in the field of biomaterials or organ ona chips and especially with polymeric microfabrication, hydrogels chemistry and cell culture.

As a formal qualification, you must hold a PhD degree (or equivalent).

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2 years. Stating date is 1 January 2025 (or according to mutual agreement). The position is a full-time position.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Associate Professor Martin Dufva, [email protected].

You can read more about DTU Health Tech at www.healthtech.dtu.dk.

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 4 December 2024 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Academic Diplomas (MSc/PhD – in English)
• List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

DTU Health Tech
With a vision to improve health and quality of life through technology, DTU Health Tech engages in research, education, and innovation based on technical and natural science. We educate tomorrow’s health tech engineers and create the foundation for new and innovative services and technologies for the globally expanding healthcare sector with its demands for the most advanced technological solutions. DTU Health Tech’s expertise can be described through five overall research areas: Diagnostic Imaging, Digital Health, Personalised Therapy, Precision Diagnostics, and Sensory and Neural Technology. Our technologies and solutions are developed with the aim of benefiting people and creating value for society. The department has a scientific staff of about 210 persons, 140 PhD Students, and a technical/administrative support staff of about 100 persons of which a large majority contributes to our research infrastructure and related commercial activities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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