Postdoctoral Researcher in Precision Medicine at the Department of Genomic Medicine, Rigshospitalet

The Department of Genomic Medicine at Rigshospitalet is seeking a highly motivated molecular biologist, an MD, or another academic researcher with relevant background to join our team.

Position details:

• Start date: Preferably January 1st, 2025, or shortly thereafter
• Duration: 3 years
• Application deadline: Friday, December 6th, 2024

The position is a part of a research group led by Chief Physician, Maria Rossing and funded by a grant from the Danish Cancer Society.

About us:
Our research group is dedicated to advancing precision and personalized medicine through state-of-the art diagnostic techniques and high-throughput methodologies. Our overall goal is to expand access to targeted treatment, benefiting more patients.

Project Details
The focus of this project is to develop integrative precision medicine approaches that enhance access to targeted treatment for cancer patients. Specifically, we investigate molecular deficiencies in Homologous Recombination DNA repair (HRR) pathway, which can be targeted using precision medicine. Identification of HRR deficiencies (HRD) in tumors are currently performed sub optimally, resulting in fewer HRD-positive cancer patients benefiting from targeted treatment.

The project aims to:

• Functionally explore HRR genetic variants observed in cancer patients using cell-based functional assays
• Analyze genome instability, chromosomal rearrangements, and mutational signatures in tumor samples.

• Characterize new HRR genetic variants using CRISPR/Cas9 technology and relevant functional assays
• Apply methodologies such as high-throughput sequencing technologies, FACS, advanced microscopy, cell culture and molecular biology assays, and CRISPR/Cas9 gene editing

Prior knowledge of at least one of these methodologies is preferred.

For more information about the group, visit: https://www.rigshospitalet.dk/english/research-and-innovation/units-and-groups/Pages/genomics-based-precision-and-personalized-medicine-research-group.aspx

Qualifications
We are looking for a highly motivated and ambitious scientist with the following qualifications:

• A PhD in Medicine, Life Sciences, or a related field, with a focus on cancer biology, cancer genetics, biochemistry
• A strong desire to contribute to impactful research
• A collaborative mindset with the ability to work independently
• Experimental expertise in DNA repair and genome maintenance pathways
• A strong publication record in peer-reviewed journals
• A PhD degree completed before the application deadline
• Fluency in English with excellent written and oral communication skills
• Preferably, experience in CRISPR-Cas9 gene editing, cell biology, microscopy, molecular biology, and biochemistry

Place of employment
The position is based in the Rossing group at the Department of Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Rigshospitalet is one of Denmark’s leading hospitals (www.rigshospitalet.dk) and is located in central Copenhagen.

Terms of employment

• Fixed-term position limited to a period of 3 years
• The average weekly working hours are 37 hours
• Salary, pension, and employment conditions are in accordance with the Danish Region’s guidelines

Application process
Your application must be submitted electronically by clicking ‘Apply now’ before December 6th, 23.59 (Copenhagen local time).

Required documents (in PDF-format)

• Motivation letter (1 - 2 pages maximum) describing your relevant expertise, research interest and career plans
• CV including education, work/research experience, language skills and other relevant qualifications
• Certified copies of:
  • PhD certificate (of superviser’s statement if pending)
  • Master’s degree
• Academic transcripts for relevant degrees
• Complete list of publications
• Optional: Letter(s) of recommendation

Note: Only applications submitted through the electronic system will be considered. Application received via email or other platforms will be not processed due to administrative reasons. We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

Recruitment Process

• Eligible applicants will be evaluated based on their CV, motivation letter and supporting documents
• Short-listed candidates will be invited for an on-site or virtual interview
• All applicants will be notified once the selection process is completed

Contact information
For further information about the positions, please contact Maria Rossing at [email protected].

Department: Ny org

Blegdamsvej 9, København Ø

Lokation: Rigshospitalet - Blegdamsvej