Profil #16505

I am competent in scientific support on both process development and manufacturing production. For the last 3+ years, I worked as a downstream scientist in a pharma company (Bavarian Nordic), and thereby I became a downstream and purification expert. I also got a good knowledge and experience on upstream and cell culture.
Downstream Purification Productive Initiative Experienced  
Opdateret 11. april 2021
Min uddannelse
2005 - 2009

ph.d. (alm.)

Danmarks Tekniske Universitet - DTU

My PhD study focused on the development of new ways to produce ceramides, which are active components in pharmaceutical and cosmetic industries.
  • Efficient and scalable methods were developed for the production of ceramide
  • Expertise on enzyme technology, membrane technology, lipid technology and process development
  • Experience on experiment design and statistical analysis
    • • Seven peer reviewed publications on international journals and books.
    Uddannelsesområde: Kemi, Biotek & Materialer
    Periode: marts 2005 - januar 2009
    2002 - 2005

    Master

    Danmarks Tekniske Universitet - DTU

    Master project “Optimization of Enzymatic Modification of Sphingomyelin”
    • Broad knowledge and lab experience on Biotechnology, including fermentation, purification, metabolic engineering, molecular biology, and microbiology, etc.
    Uddannelsesområde: Kemi, Biotek & Materialer
    Periode: september 2002 - marts 2005
    1996 - 2000

    Bachelor

    Anden uddannelsesinstitution i udlandet

    Bachelor's degree, Pharmacy Medicine, Shanxi Medical University, China
    Bachelor Thesis “The Lithontriptic Effect of Peppermint Extraction”
  • Broad knowledge and lab experience on pharmacology, organic chemistry, biochemistry, GMP, physiology, and pathology, etc.
    • • One peer reviewed article regarding the Bachelor thesis was published in a journal.
    Uddannelsesområde: Medicinal & Sundhed
    Periode: september 1996 - juli 2000
    Min erhvervserfaring
    2013 - 2017

    Downstream scientist

    Bavarian Nordic A/S

    Bavarian Nordic is a pharmaceutical company focused on the development, manufacturing and commercialization of cancer immunotherapies and vaccines for infectious diseases. I worked in Process Development department, which plays a crucial role on process investigation, new process development, process validation for new products, and support on manufacturing production.

    I worked primarily as a downstream scientist and also have a good knowledge and experience on upstream processes in cell culture.
  • Investigation and optimization of downstream and upstream process at pilot scale
  • Developing new processes, e.g. new TFF process, to replace the current process in production
  • Production process design for new products.
  • Scientific support on process validation for new products, including DoE study, CPP evaluation, reviewing validation report, support on engineering runs, etc.
  • Process upscaling from pilot to production scale. Support and training for newly implemented process at production.
  • Tech transfer between different sites in the company and between CMO and the company.
  • Process support and troubleshooting on manufacturing production, e.g. help on deviations, OOS and change control from GMP batches.
  • Preparation, draft review and record review of Master Batch Journal for the production of preclinical material at pilot scale.
  • Selection and qualification of equipment at pilot plant, e.g. TFF, Sonicator, pump, etc. Help on qualification of equipment in manufacturing.
  • Analysis method setup and validation in PD, e.g. SDS-PAGE, BCA, UV280, viscosity, density, DNA gel.
  • Close collaboration with different departments, e.g. R&D, Production, QC, QA, PM, etc.
  • I got thorough training on cGMP and documentation. I practiced them every day.
  • Our group applied LEAN in the daily work, and used several whiteboards for planning the tasks, organizing staff training, and KPI, etc.
    • • Writing and reviewing study plans, protocols, SOP, reports and deviations.
    Arbejdsområde: Produktion
    Periode: juni 2013 - januar 2017
    2012 - 2013

    Post doc

    Copenhagen University

    • Developing lipid formulation to improve oral drug delivery system
    • Developing lipid quantification methods (GC, HPTLC, HPLC)
    • In vitro lipolysis (Simulation of intestinal environment)
    • Two peer reviewed articles were published in international journals
    Arbejdsområde: Forskning & Udvikling
    Periode: juni 2012 - april 2013
    2010 - 2011

    Post doc

    Technical University of Denmark

    I joined in a project, “Enzymatic production of human milk oligosaccharides”
    • Protein purification process development (Affinity chromatography, Size exclusion chromatography)
    • Enzyme (sialyl-transferase) assays development by fluorescent and absorbance
    • Protein characterization (SDS-PAGE, BCA, Silver staining, Western blot, etc.)
    Arbejdsområde: Forskning & Udvikling
    Periode: april 2010 - april 2011
    Mine kompetencer
    Evner
    affinity and size exclusion chromatography cell lysis centrifugation depth filtration diafiltration dna degradation doe design downstream holding time study impurity clearance liquid-liquid and liquid-particle mixing pilot production problem solving process development root cause investigation sonication str incubation tech transfer ultracentrifugation upscaling upstream viafuge viscosity microfiltration process investigation process support and training roller bottle tangential flow filtration ultrafiltration validation wave bag
    Sprog på arbejdsniveau
    dansk (midt niveau) engelsk kinesisk
    Mine præferencer
    Jobtype
    Fuldtidsjob Vikariat
    Arbejdsområde
    Forskning & Udvikling Produktion
    Geografi
    Bornholm Fyn Grønland & Færøerne Midtjylland Nordjylland Nordsjælland Storkøbenhavn Sydsjælland & Øer Sydvestjylland (Esbjerg) Sydøstjylland Sønderjylland Udlandet (Norge) Udlandet (Sverige) Udlandet (øvrige) Vestjylland Vestsjælland Øresundsregionen Østjylland (Aarhus) Østsjælland
    Læs mere / links
    https://www.linkedin.com/in/lo...
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